KMID : 0355620130390060292
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Journal of Korean Association of Oral and Maxillofacial Surgeons 2013 Volume.39 No. 6 p.292 ~ p.296
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Verruciform xanthoma of the palatal gingiva: a report of two cases
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Ryu Da-Jung
Lee Sang-Hoon Yuk Jong-In Kim Hyung-Jun Huh Jong-Ki Park Kwang-Ho
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Abstract
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Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has indistinct clinical features, making histopathological examination necessary for a definitive diagnosis. Histologically, VX is characterized by parakeratosis, rete ridges with uniform depth, and an accumulation of the foam cells, which are also known as the ¡°xanthoma cells¡±. These foam cells test positive for antibodies, such as CD-68 and vimentin; it is thought that VX foam cells are derived from the monocyte-macrophage lineage, and that VX¡¯s pathogenic mechanism is partly related to an immune mechanism. Nevertheless, the pathogenesis of VX remains unclear. VX can be treated by surgical excision; other medical, chemical, and radiological treatments are not required postoperatively. Recurrence and malignant transformation of VX are rare. Two patients, each with a mass of unknown origin on the palatal gingiva, were presented at our clinic. Excisional biopsies of the masses were performed for a histological diagnosis after clinical and radiological examinations. Histological examination confirmed a diagnosis of VX in both cases.
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KEYWORD
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Verruciform xanthoma, Mouth, Foam cells, Immune mechanism
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